Although sharing many mutual goals and policies, the United States and Europe approach decision-making very differently. This reflects their respective differences in organization, government, economic, and legal frameworks. The effective management of outer space is a global responsibility that transcends nations and regions. At the same time it is a relatively small segment of national activities, but it is now intricately entwined in almost all international issues. Finding a path for nations and economies to cooperate and to compete in space is an ongoing challenge, even for nations with long histories of mutual engagement and agreements. This talk will highlight major issues with regard to space in the United States and Europe looking toward the growth and sustainability of both governments and private entities in future space endeavors.